Ontology highlight
ABSTRACT:
SUBMITTER: Alguel Y
PROVIDER: S-EPMC4837479 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Alguel Yilmaz Y Amillis Sotiris S Leung James J Lambrinidis George G Capaldi Stefano S Scull Nicola J NJ Craven Gregory G Iwata So S Armstrong Alan A Mikros Emmanuel E Diallinas George G Cameron Alexander D AD Byrne Bernadette B
Nature communications 20160418
The uric acid/xanthine H(+) symporter, UapA, is a high-affinity purine transporter from the filamentous fungus Aspergillus nidulans. Here we present the crystal structure of a genetically stabilized version of UapA (UapA-G411VΔ1-11) in complex with xanthine. UapA is formed from two domains, a core domain and a gate domain, similar to the previously solved uracil transporter UraA, which belongs to the same family. The structure shows UapA in an inward-facing conformation with xanthine bound to re ...[more]