Ontology highlight
ABSTRACT:
SUBMITTER: Hummel TR
PROVIDER: S-EPMC4837895 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Hummel Trent R TR Jessen Walter J WJ Miller Shyra J SJ Kluwe Lan L Mautner Victor F VF Wallace Margaret R MR Lázaro Conxi C Page Grier P GP Worley Paul F PF Aronow Bruce J BJ Schorry Elizabeth K EK Ratner Nancy N
Clinical cancer research : an official journal of the American Association for Cancer Research 20100825 20
<h4>Purpose</h4>Plexiform neurofibromas (pNF) are Schwann cell tumors found in a third of individuals with neurofibromatosis type 1 (NF1). pNF can undergo transformation to malignant peripheral nerve sheath tumors (MPNST). There are no identified serum biomarkers of pNF tumor burden or transformation to MPNST. Serum biomarkers would be useful to verify NF1 diagnosis, monitor tumor burden, and/or detect transformation.<h4>Experimental design</h4>We used microarray gene expression analysis to defi ...[more]