Ontology highlight
ABSTRACT:
SUBMITTER: Seo BR
PROVIDER: S-EPMC4837896 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Seo Bo Ri BR Bhardwaj Priya P Choi Siyoung S Gonzalez Jacqueline J Andresen Eguiluz Roberto C RC Wang Karin K Mohanan Sunish S Morris Patrick G PG Du Baoheng B Zhou Xi K XK Vahdat Linda T LT Verma Akanksha A Elemento Olivier O Hudis Clifford A CA Williams Rebecca M RM Gourdon Delphine D Dannenberg Andrew J AJ Fischbach Claudia C
Science translational medicine 20150801 301
Obesity and extracellular matrix (ECM) density are considered independent risk and prognostic factors for breast cancer. Whether they are functionally linked is uncertain. We investigated the hypothesis that obesity enhances local myofibroblast content in mammary adipose tissue and that these stromal changes increase malignant potential by enhancing interstitial ECM stiffness. Indeed, mammary fat of both diet- and genetically induced mouse models of obesity were enriched for myofibroblasts and s ...[more]