Reactive Self-Assembly of Polymers and Proteins to Reversibly Silence a Killer Protein.
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ABSTRACT:
SUBMITTER: Ventura J
PROVIDER: S-EPMC4838044 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
Reactive Self-Assembly of Polymers and Proteins to Reversibly Silence a Killer Protein.
Ventura Judy J Eron Scott J SJ González-Toro Daniella C DC Raghupathi Kishore K Wang Feng F Hardy Jeanne A JA Thayumanavan S S
Biomacromolecules 20150910 10
Conjugation of biologically active proteins to polymeric materials is of great interest in the treatment of cancer and other diseases of protein deficiency. The conjugation of such biomacromolecules is challenging both due to their hydrophilicity and propensity to denature under non-native conditions. We describe a novel reactive self-assembly approach to "wrap" a protein with polymers, simultaneously protecting its delicate folded state and silencing its enzymatic activity. This approach has be ...[more]
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