Ontology highlight
ABSTRACT:
SUBMITTER: Diener C
PROVIDER: S-EPMC4838304 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Diener Christian C Garza Ramos Martínez Georgina G Moreno Blas Daniel D Castillo González David A DA Corzo Gerardo G Castro-Obregon Susana S Del Rio Gabriel G
PLoS computational biology 20160420 4
Multifunctionality is a common trait of many natural proteins and peptides, yet the rules to generate such multifunctionality remain unclear. We propose that the rules defining some protein/peptide functions are compatible. To explore this hypothesis, we trained a computational method to predict cell-penetrating peptides at the sequence level and learned that antimicrobial peptides and DNA-binding proteins are compatible with the rules of our predictor. Based on this finding, we expected that de ...[more]