Ontology highlight
ABSTRACT:
SUBMITTER: Huang J
PROVIDER: S-EPMC4838338 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Huang Jianguo J Zhang Ali A Ho Tsui-Ting TT Zhang Ziqiang Z Zhou Nanjiang N Ding Xianfeng X Zhang Xu X Xu Min M Mo Yin-Yuan YY
Nucleic acids research 20151209 7
Linc-RoR was originally identified to be a regulator for induced pluripotent stem cells in humans and it has also been implicated in tumorigenesis. However, the underlying mechanism of Linc-RoR-mediated gene expression in cancer is poorly understood. The present study demonstrates that Linc-RoR plays an oncogenic role in part through regulation of c-Myc expression. Linc-RoR knockout (KO) suppresses cell proliferation and tumor growth. In particular, Linc-RoR KO causes a significant decrease in c ...[more]