Ontology highlight
ABSTRACT:
SUBMITTER: Lim WF
PROVIDER: S-EPMC4838343 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Lim Wooi F WF Burdach Jon J Funnell Alister P W AP Pearson Richard C M RC Quinlan Kate G R KG Crossley Merlin M
Nucleic acids research 20151215 7
Transcription factors are often regarded as having two separable components: a DNA-binding domain (DBD) and a functional domain (FD), with the DBD thought to determine target gene recognition. While this holds true for DNA bindingin vitro, it appears thatin vivoFDs can also influence genomic targeting. We fused the FD from the well-characterized transcription factor Krüppel-like Factor 3 (KLF3) to an artificial zinc finger (AZF) protein originally designed to target the Vascular Endothelial Grow ...[more]