Differential Dopamine Regulation of Ca(2+) Signaling and Its Timing Dependence in the Nucleus Accumbens.
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ABSTRACT:
SUBMITTER: Swapna I
PROVIDER: S-EPMC4838497 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Publications
Differential Dopamine Regulation of Ca(2+) Signaling and Its Timing Dependence in the Nucleus Accumbens.
Swapna Immani I Bondy Brian B Morikawa Hitoshi H
Cell reports 20160407 3
Dopamine action in the nucleus accumbens (NAc) is thought to drive appetitive behavior and Pavlovian reward learning. However, it remains controversial how dopamine achieves these behavioral effects by regulating medium spiny projection neurons (MSNs) of the NAc, especially on a behaviorally relevant timescale. Metabotropic glutamate receptor (mGluR)-induced Ca(2+) signaling dependent on the Ca(2+)- releasing messenger inositol 1,4,5-triphosphate (IP3) plays a critical role in controlling neuron ...[more]
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