Ontology highlight
ABSTRACT:
SUBMITTER: Drennen B
PROVIDER: S-EPMC4838500 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Drennen Brandon B Scheenstra Jacob A JA Yap Jeremy L JL Chen Lijia L Lanning Maryanna E ME Roth Braden M BM Wilder Paul T PT Fletcher Steven S
ChemMedChem 20160204 8
The disruption of aberrant protein-protein interactions (PPIs) with synthetic agents remains a challenging goal in contemporary medicinal chemistry but some progress has been made. One such dysregulated PPI is that between the anti-apoptotic Bcl-2 proteins, including myeloid cell leukemia-1 (Mcl-1), and the α-helical Bcl-2 homology-3 (BH3) domains of its pro-apoptotic counterparts, such as Bak. Herein, we describe the discovery of small-molecule inhibitors of the Mcl-1 oncoprotein based on a nov ...[more]