Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer.
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ABSTRACT:
SUBMITTER: Akoury E
PROVIDER: S-EPMC4838641 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer.
Akoury Elias E Mukrasch Marco D MD Biernat Jacek J Tepper Katharina K Ozenne Valery V Mandelkow Eckhard E Blackledge Martin M Zweckstetter Markus M
Protein science : a publication of the Protein Society 20160324 5
Misfolding of the microtubule-associated protein Tau is a hallmark of Alzheimer disease and several other neurodegenerative disorders. Because of the dynamic nature of the Tau protein, little is known about the changes in Tau structure that occur during misfolding. Here we studied the structural consequences upon binding of the repeat domain of Tau, which plays a key role in pathogenic aggregation, to an aggregation enhancer. By combining NMR experiments with molecular simulations we show that b ...[more]
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