Ontology highlight
ABSTRACT:
SUBMITTER: Martinez-Rocha AL
PROVIDER: S-EPMC4838825 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Martinez-Rocha Ana Lilia AL Woriedh Mayada M Chemnitz Jan J Willingmann Peter P Kröger Cathrin C Hadeler Birgit B Hauber Joachim J Schäfer Wilhelm W
Scientific reports 20160421
Activation of eukaryotic translation initiation factor eIF5A requires a posttranslational modification, forming the unique amino acid hypusine. This activation is mediated by two enzymes, deoxyhypusine synthase, DHS, and deoxyhypusine hydroxylase, DOHH. The impact of this enzymatic complex on the life cycle of a fungal pathogen is unknown. Plant pathogenic ascomycetes possess a single copy of the eIF5A activated by hypusination. We evaluated the importance of imbalances in eIF5A hypusination in ...[more]