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Resveratrol enhances HBV replication through activating Sirt1-PGC-1?-PPAR? pathway.


ABSTRACT: The population of hepatitis B combined with a number of metabolic disorders is increasing significantly. Resveratrol (RSV) has been used as a preclinical drug for the treatment of the metabolic disorders. However, the impact of RSV on HBV replication remains unknown. In this study, the HBV-expressing hepatocelluar carcinoma cell line and mouse model created by hydrodynamic injection of viral DNA were used. We found that RSV activates Sirt1, which in turn deacetylates PGC-1? and subsequently increases the transcriptional activity of PPAR?, leading to the enhanced HBV transcription and replication in vitro and in vivo. In addition, we found that this pathway is also required for fasting-induced HBV transcription. Taken together, this study identifies that RSV enhances HBV transcription and replication especially acting on the core promoter, which depends on Sirt1-PGC-1?-PPAR? pathway. We conclude that RSV may exacerbate the progression of hepatitis B and that patients with hepatitis B infection should be cautious taking RSV as a dietary supplement.

SUBMITTER: Shi Y 

PROVIDER: S-EPMC4838842 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Resveratrol enhances HBV replication through activating Sirt1-PGC-1α-PPARα pathway.

Shi Yixian Y   Li Yongjun Y   Huang Chenjie C   Ying Lixiong L   Xue Jihua J   Wu Haicong H   Chen Zhi Z   Yang Zhenggang Z  

Scientific reports 20160421


The population of hepatitis B combined with a number of metabolic disorders is increasing significantly. Resveratrol (RSV) has been used as a preclinical drug for the treatment of the metabolic disorders. However, the impact of RSV on HBV replication remains unknown. In this study, the HBV-expressing hepatocelluar carcinoma cell line and mouse model created by hydrodynamic injection of viral DNA were used. We found that RSV activates Sirt1, which in turn deacetylates PGC-1α and subsequently incr  ...[more]

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