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ABSTRACT: Objective
To explore the parametric characteristics of diffusional kurtosis imaging (DKI) in the brain development of healthy preterm infants.Materials and methods
Conventional magnetic resonance imaging (MRI) and DKI were performed in 35 preterm (29 to 36 weeks gestational age [GA]; scanned at 33 to 44 weeks postmenstrual age [PMA]) and 10 term infants (37.4 to 40.7 weeks GA; scanned at 38.3 to 42.9 weeks PMA). Fractional anisotropy (FA), mean diffusivity (MD) and mean kurtosis (MK) values from 8 regions of interest, including both white matter (WM) and gray matter (GM), were obtained.Results
MK and FA values were positively correlated with PMA in most selected WM regions, such as the posterior limbs of the internal capsule (PLIC) and the splenium of the corpus callosum (SCC). The positive correlation between MK value and PMA in the deep GM region was higher than that between FA and PMA. The MK value gradually decreased from the PLIC to the cerebral lobe. In addition, DKI parameters exhibited subtle differences in the parietal WM between the preterm and term control groups.Conclusions
MK may serve as a more reliable imaging marker of the normal myelination process and provide a more robust characterization of deep GM maturation.
SUBMITTER: Shi J
PROVIDER: S-EPMC4839617 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Shi Jingjing J Chang Liwen L Wang Jian J Zhang Shun S Yao Yihao Y Zhang Shuixia S Jiang Rifeng R Guo Linying L Guan Hanxiong H Zhu Wenzhen W
PloS one 20160421 4
<h4>Objective</h4>To explore the parametric characteristics of diffusional kurtosis imaging (DKI) in the brain development of healthy preterm infants.<h4>Materials and methods</h4>Conventional magnetic resonance imaging (MRI) and DKI were performed in 35 preterm (29 to 36 weeks gestational age [GA]; scanned at 33 to 44 weeks postmenstrual age [PMA]) and 10 term infants (37.4 to 40.7 weeks GA; scanned at 38.3 to 42.9 weeks PMA). Fractional anisotropy (FA), mean diffusivity (MD) and mean kurtosis ...[more]