Ontology highlight
ABSTRACT:
SUBMITTER: Cadwell CR
PROVIDER: S-EPMC4840019 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Cadwell Cathryn R CR Palasantza Athanasia A Jiang Xiaolong X Berens Philipp P Deng Qiaolin Q Yilmaz Marlene M Reimer Jacob J Shen Shan S Bethge Matthias M Tolias Kimberley F KF Sandberg Rickard R Tolias Andreas S AS
Nature biotechnology 20151221 2
Despite the importance of the mammalian neocortex for complex cognitive processes, we still lack a comprehensive description of its cellular components. To improve the classification of neuronal cell types and the functional characterization of single neurons, we present Patch-seq, a method that combines whole-cell electrophysiological patch-clamp recordings, single-cell RNA-sequencing and morphological characterization. Following electrophysiological characterization, cell contents are aspirate ...[more]