Cell Fate Decisions During Breast Cancer Development.
Ontology highlight
ABSTRACT:
SUBMITTER: Gross K
PROVIDER: S-EPMC4840277 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Publications
Cell Fate Decisions During Breast Cancer Development.
Gross Kayla K Wronski Ania A Skibinski Adam A Phillips Sarah S Kuperwasser Charlotte C
Journal of developmental biology 20160122 1
During the formation of breast cancer, many genes become altered as cells evolve progressively from normal to a pre-malignant to a malignant state of growth. How mutations in genes lead to specific subtypes of human breast cancer is only partially understood. Here we review how initial genetic or epigenetic alterations within mammary epithelial cells (MECs) can alter cell fate decisions and put pre-malignant cells on a path towards cancer development with specific phenotypes. Understanding the e ...[more]
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