Ontology highlight
ABSTRACT:
SUBMITTER: Sun H
PROVIDER: S-EPMC4840416 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Sun Huiyong H Pan Peichen P Tian Sheng S Xu Lei L Kong Xiaotian X Li Youyong Y Dan Li Hou Tingjun T
Scientific reports 20160422
The MIEC-SVM approach, which combines molecular interaction energy components (MIEC) derived from free energy decomposition and support vector machine (SVM), has been found effective in capturing the energetic patterns of protein-peptide recognition. However, the performance of this approach in identifying small molecule inhibitors of drug targets has not been well assessed and validated by experiments. Thereafter, by combining different model construction protocols, the issues related to develo ...[more]