Infant birth weight and third trimester maternal plasma markers of vascular integrity: the MIREC study.
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ABSTRACT: Background
There is paucity of information on mechanisms constituting adverse birth outcomes. We assessed here the relationship between vascular integrity and adverse birth effects.Methods and results
Third trimester maternal plasma (n = 144) from the Maternal-Infant Research on Environmental Chemicals Study (MIREC) was analysed for vascular, inflammatory and oxidative stress markers by HPLC-fluorescence, protein array and EIA method. Analysis of the <25th and >75th percentile birth weight subgroups revealed markers associated with birth weight (ETs, MMP-9, VEGF, and 8-isoPGF-2?) and gestational age (ET-1, MMP-2, and VEGF).Conclusions
Mechanistic insights into adverse birth outcome pathways can be achieved by integrating information on multiple biomarkers, physiology using systems biology approach.
SUBMITTER: Kumarathasan P
PROVIDER: S-EPMC4841026 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Infant birth weight and third trimester maternal plasma markers of vascular integrity: the MIREC study.
Kumarathasan Premkumari P Vincent Renaud R Bielecki Agnieszka A Blais Erica E Blank Katrin K Das Dharani D Karthikeyan Subramanian S Cakmak Sabit S Fisher Mandy M Arbuckle Tye T Fraser William W
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20160222 3
<h4>Background</h4>There is paucity of information on mechanisms constituting adverse birth outcomes. We assessed here the relationship between vascular integrity and adverse birth effects.<h4>Methods and results</h4>Third trimester maternal plasma (n = 144) from the Maternal-Infant Research on Environmental Chemicals Study (MIREC) was analysed for vascular, inflammatory and oxidative stress markers by HPLC-fluorescence, protein array and EIA method. Analysis of the <25th and >75th percentile bi ...[more]
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