Ontology highlight
ABSTRACT:
SUBMITTER: Swinstead EE
PROVIDER: S-EPMC4842147 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Swinstead Erin E EE Miranda Tina B TB Paakinaho Ville V Baek Songjoon S Goldstein Ido I Hawkins Mary M Karpova Tatiana S TS Ball David D Mazza Davide D Lavis Luke D LD Grimm Jonathan B JB Morisaki Tatsuya T Grøntved Lars L Presman Diego M DM Hager Gordon L GL
Cell 20160407 3
The estrogen receptor (ER), glucocorticoid receptor (GR), and forkhead box protein 1 (FoxA1) are significant factors in breast cancer progression. FoxA1 has been implicated in establishing ER-binding patterns though its unique ability to serve as a pioneer factor. However, the molecular interplay between ER, GR, and FoxA1 requires further investigation. Here we show that ER and GR both have the ability to alter the genomic distribution of the FoxA1 pioneer factor. Single-molecule tracking experi ...[more]