Ontology highlight
ABSTRACT:
SUBMITTER: Drilon A
PROVIDER: S-EPMC4843186 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Drilon A A Li G G Dogan S S Gounder M M Shen R R Arcila M M Wang L L Hyman D M DM Hechtman J J Wei G G Cam N R NR Christiansen J J Luo D D Maneval E C EC Bauer T T Patel M M Liu S V SV Ou S H I SH Farago A A Shaw A A Shoemaker R F RF Lim J J Hornby Z Z Multani P P Ladanyi M M Berger M M Katabi N N Ghossein R R Ho A L AL
Annals of oncology : official journal of the European Society for Medical Oncology 20160215 5
<h4>Background</h4>Mammary analogue secretory carcinoma (MASC) is a recently described pathologic entity. We report the case of a patient with an initial diagnosis of salivary acinic cell carcinoma later reclassified as MASC after next-generation sequencing revealed an ETV6-NTRK3 fusion.<h4>Patients and methods</h4>This alteration was targeted with the pan-Trk inhibitor entrectinib (Ignyta), which possesses potent in vitro activity against cell lines containing various NTRK1/2/3 fusions.<h4>Resu ...[more]