Dataset Information
Response to angiotensin blockade with irbesartan in a patient with metastatic colorectal cancer.
Ontology highlight
ABSTRACT: Background
A patient suffering from metastatic colorectal cancer, treatment-related toxicity and resistance to standard chemotherapy and radiation was assessed as part of a personalized oncogenomics initiative to derive potential alternative therapeutic strategies.Patients and methods
Whole-genome and transcriptome sequencing was used to interrogate a metastatic tumor refractory to standard treatments of a patient with mismatch repair-deficient metastatic colorectal cancer.Results
Integrative genomic analysis indicated overexpression of the AP-1 transcriptional complex suggesting experimental therapeutic rationales, including blockade of the renin-angiotensin system. This led to the repurposing of the angiotensin II receptor antagonist, irbesartan, as an anticancer therapy, resulting in the patient experiencing a dramatic and durable response.Conclusions
This case highlights the utility of comprehensive integrative genomic profiling and bioinformatics analysis to provide hypothetical rationales for personalized treatment options.
SUBMITTER: Jones MR
PROVIDER: S-EPMC4843189 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Response to angiotensin blockade with irbesartan in a patient with metastatic colorectal cancer.
Annals of oncology : official journal of the European Society for Medical Oncology 20160218 5
<h4>Background</h4>A patient suffering from metastatic colorectal cancer, treatment-related toxicity and resistance to standard chemotherapy and radiation was assessed as part of a personalized oncogenomics initiative to derive potential alternative therapeutic strategies.<h4>Patients and methods</h4>Whole-genome and transcriptome sequencing was used to interrogate a metastatic tumor refractory to standard treatments of a patient with mismatch repair-deficient metastatic colorectal cancer.<h4>Re ...[more]