Ontology highlight
ABSTRACT:
SUBMITTER: Bradley SJ
PROVIDER: S-EPMC4843461 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Bradley Sophie J SJ Wiegman Coen H CH Iglesias Max Maza MM Kong Kok Choi KC Butcher Adrian J AJ Plouffe Bianca B Goupil Eugénie E Bourgognon Julie-Myrtille JM Macedo-Hatch Timothy T LeGouill Christian C Russell Kirsty K Laporte Stéphane A SA König Gabriele M GM Kostenis Evi E Bouvier Michel M Chung Kian Fan KF Amrani Yassine Y Tobin Andrew B AB
Proceedings of the National Academy of Sciences of the United States of America 20160408 16
G protein-coupled receptors (GPCRs) are known to initiate a plethora of signaling pathways in vitro. However, it is unclear which of these pathways are engaged to mediate physiological responses. Here, we examine the distinct roles of Gq/11-dependent signaling and receptor phosphorylation-dependent signaling in bronchial airway contraction and lung function regulated through the M3-muscarinic acetylcholine receptor (M3-mAChR). By using a genetically engineered mouse expressing a G protein-biased ...[more]