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Reduced oxygen utilization in septic shock: disorder or adaptation?

ABSTRACT: A fall in oxygen utilization during septic or endotoxic shock is thought to reflect circulatory hypoxia or mitochondrial dysfunction, but these pathology-oriented hypotheses do not explain all clinical observations. Here we discuss an alternative hypothesis of how oxygen utilization could fall as the result of a physiological thermometabolic adaptation.

SUBMITTER: Steiner AA 

PROVIDER: S-EPMC4843942 | biostudies-literature | 2015 Oct-Dec

REPOSITORIES: biostudies-literature

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Reduced oxygen utilization in septic shock: disorder or adaptation?

Steiner Alexandre A AA  

Temperature (Austin, Tex.) 20150205 4

A fall in oxygen utilization during septic or endotoxic shock is thought to reflect circulatory hypoxia or mitochondrial dysfunction, but these pathology-oriented hypotheses do not explain all clinical observations. Here we discuss an alternative hypothesis of how oxygen utilization could fall as the result of a physiological thermometabolic adaptation. ...[more]

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