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4-Hz oscillations synchronize prefrontal-amygdala circuits during fear behavior.

ABSTRACT: Fear expression relies on the coordinated activity of prefrontal and amygdala circuits, yet the mechanisms allowing long-range network synchronization during fear remain unknown. Using a combination of extracellular recordings, pharmacological and optogenetic manipulations, we found that freezing, a behavioral expression of fear, temporally coincided with the development of sustained, internally generated 4-Hz oscillations in prefrontal-amygdala circuits. 4-Hz oscillations predict freezing onset and offset and synchronize prefrontal-amygdala circuits. Optogenetic induction of prefrontal 4-Hz oscillations coordinates prefrontal-amygdala activity and elicits fear behavior. These results unravel a sustained oscillatory mechanism mediating prefrontal-amygdala coupling during fear behavior.

SUBMITTER: Karalis N

PROVIDER: S-EPMC4843971 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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4-Hz oscillations synchronize prefrontal-amygdala circuits during fear behavior.

Karalis Nikolaos N Dejean Cyril C Chaudun Fabrice F Khoder Suzana S Rozeske Robert R RR Wurtz Hélène H Bagur Sophie S Benchenane Karim K Sirota Anton A Courtin Julien J Herry Cyril C

Nature neuroscience 20160215 4

Fear expression relies on the coordinated activity of prefrontal and amygdala circuits, yet the mechanisms allowing long-range network synchronization during fear remain unknown. Using a combination of extracellular recordings, pharmacological and optogenetic manipulations, we found that freezing, a behavioral expression of fear, temporally coincided with the development of sustained, internally generated 4-Hz oscillations in prefrontal-amygdala circuits. 4-Hz oscillations predict freezing onset ...[more]

PMID: 26878674

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