Ontology highlight
ABSTRACT:
SUBMITTER: Karalis N
PROVIDER: S-EPMC4843971 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Nature neuroscience 20160215 4
Fear expression relies on the coordinated activity of prefrontal and amygdala circuits, yet the mechanisms allowing long-range network synchronization during fear remain unknown. Using a combination of extracellular recordings, pharmacological and optogenetic manipulations, we found that freezing, a behavioral expression of fear, temporally coincided with the development of sustained, internally generated 4-Hz oscillations in prefrontal-amygdala circuits. 4-Hz oscillations predict freezing onset ...[more]