Ontology highlight
ABSTRACT:
SUBMITTER: Hilbert BJ
PROVIDER: S-EPMC4844192 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Hilbert Brendan J BJ Morris Benjamin L BL Ellis Keith C KC Paulsen Janet L JL Schiffer Celia A CA Grossman Steven R SR Royer William E WE
ACS chemical biology 20150130 4
Oncogenic transcriptional coregulators C-terminal Binding Protein (CtBP) 1 and 2 possess regulatory d-isomer specific 2-hydroxyacid dehydrogenase (D2-HDH) domains that provide an attractive target for small molecule intervention. Findings that the CtBP substrate 4-methylthio 2-oxobutyric acid (MTOB) can interfere with CtBP oncogenic activity in cell culture and in mice confirm that such inhibitors could have therapeutic benefit. Recent crystal structures of CtBP 1 and 2 revealed that MTOB binds ...[more]