Dataset Information

A genome-wide identified risk variant for PTSD is a methylation quantitative trait locus and confers decreased cortical activation to fearful faces.

ABSTRACT: Genetic factors appear to be highly relevant to predicting differential risk for the development of post-traumatic stress disorder (PTSD). In a discovery sample, we conducted a genome-wide association study (GWAS) for PTSD using a small military cohort (Systems Biology PTSD Biomarkers Consortium; SBPBC, N?=?147) that was designed as a case-controlled sample of highly exposed, recently returning veterans with and without combat-related PTSD. A genome-wide significant single nucleotide polymorphism (SNP), rs717947, at chromosome 4p15 (N?=?147, ??=?31.34, P?=?1.28?×?10(-8) ) was found to associate with the gold-standard diagnostic measure for PTSD (the Clinician Administered PTSD Scale). We conducted replication and follow-up studies in an external sample, a larger urban community cohort (Grady Trauma Project, GTP, N?=?2006), to determine the robustness and putative functionality of this risk variant. In the GTP replication sample, SNP rs717947 associated with PTSD diagnosis in females (N?=?2006, P?=?0.005), but not males. SNP rs717947 was also found to be a methylation quantitative trait locus (meQTL) in the GTP replication sample (N?=?157, P?=?0.002). Further, the risk allele of rs717947 was associated with decreased medial and dorsolateral cortical activation to fearful faces (N?=?53, P?

SUBMITTER: Almli LM

PROVIDER: S-EPMC4844461 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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A genome-wide identified risk variant for PTSD is a methylation quantitative trait locus and confers decreased cortical activation to fearful faces.

Almli Lynn M LM Stevens Jennifer S JS Smith Alicia K AK Kilaru Varun V Meng Qian Q Flory Janine J Abu-Amara Duna D Hammamieh Rasha R Yang Ruoting R Mercer Kristina B KB Binder Elizabeth B EB Bradley Bekh B Hamilton Steven S Jett Marti M Yehuda Rachel R Marmar Charles R CR Ressler Kerry J KJ

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20150518 5

Genetic factors appear to be highly relevant to predicting differential risk for the development of post-traumatic stress disorder (PTSD). In a discovery sample, we conducted a genome-wide association study (GWAS) for PTSD using a small military cohort (Systems Biology PTSD Biomarkers Consortium; SBPBC, N = 147) that was designed as a case-controlled sample of highly exposed, recently returning veterans with and without combat-related PTSD. A genome-wide significant single nucleotide polymorphis ...[more]

PMID: 25988933

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Project description:Facial expression and gaze direction play an important role in social communication. Previous research has demonstrated the perception of anger is enhanced by direct gaze, whereas, it is unclear whether perception of fear is enhanced by averted gaze. In addition, previous research has shown the anxiety affects the processing of facial expression and gaze direction, but hasn't measured or controlled for depression. As a result, firm conclusions cannot be made regarding the impact of individual differences in anxiety and depression on perceptions of face expressions and gaze direction. The current study attempted to reexamine the effect of the anxiety level on the processing of facial expressions and gaze direction by matching participants on depression scores. A reliable psychophysical index of the range of eye gaze angles judged as being directed at oneself [the cone of direct gaze (CoDG)] was used as the dependent variable in this study. Participants were stratified into high/low trait anxiety groups and asked to judge the gaze of angry, fearful, and neutral faces across a range of gaze directions. The result showed: (1) the perception of gaze direction was influenced by facial expression and this was modulated by trait anxiety. For the high trait anxiety group, the CoDG for angry expressions was wider than for fearful and neutral expressions, and no significant difference emerged between fearful and neutral expressions; For the low trait anxiety group, the CoDG for both angry and fearful expressions was wider than for neutral, and no significant difference emerged between angry and fearful expressions. (2) Trait anxiety modulated the perception of gaze direction only in the fearful condition, such that the fearful CoDG for the high trait anxiety group was narrower than the low trait anxiety group. This demonstrated that anxiety distinctly affected gaze perception in expressions that convey threat (angry, fearful), such that a high trait anxiety level modulated the impact of indirectly threatening expressions (fearful), and did not influence responses to directly threatening expression (angry). These findings partially support the shared signal hypothesis.

Dataset Information

A genome-wide identified risk variant for PTSD is a methylation quantitative trait locus and confers decreased cortical activation to fearful faces.

Publications

A genome-wide identified risk variant for PTSD is a methylation quantitative trait locus and confers decreased cortical activation to fearful faces.

Similar Datasets

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