Ontology highlight
ABSTRACT:
SUBMITTER: Weber JP
PROVIDER: S-EPMC4844677 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Weber Jens P JP Andrásfalvy Bertalan K BK Polito Marina M Magó Ádám Á Ujfalussy Balázs B BB Makara Judit K JK
Nature communications 20160421
Nonlinear interactions between coactive synapses enable neurons to discriminate between spatiotemporal patterns of inputs. Using patterned postsynaptic stimulation by two-photon glutamate uncaging, here we investigate the sensitivity of synaptic Ca(2+) signalling and long-term plasticity in individual spines to coincident activity of nearby synapses. We find a proximodistally increasing gradient of nonlinear NMDA receptor (NMDAR)-mediated amplification of spine Ca(2+) signals by a few neighbouri ...[more]