Ontology highlight
ABSTRACT:
SUBMITTER: Hur J
PROVIDER: S-EPMC4844938 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Hur Jeonghwan J Ghosh Ambarnil A Kim Kabsun K Ta Hai Minh HM Kim Hyunju H Kim Nacksung N Hwang Hye-Yeon HY Kim Kyeong Kyu KK
Molecules and cells 20160226 4
The receptor activator of nuclear factor κB (RANK) and its ligand RANKL are key regulators of osteoclastogenesis and well-recognized targets in developing treatments for bone disorders associated with excessive bone resorption, such as osteoporosis. Our previous work on the structure of the RANK-RANKL complex revealed that Loop3 of RANK, specifically the non-canonical disulfide bond at the tip, performs a crucial role in specific recognition of RANKL. It also demonstrated that peptide mimics of ...[more]