Ontology highlight
ABSTRACT:
SUBMITTER: Nayak TK
PROVIDER: S-EPMC4845029 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Nayak Tapan Kumar TK Nayak Tapan Kumar TK Chakraborty Srirupa S Zheng Wenjun W Auerbach Anthony A
Nature communications 20160422
Adult-type nicotinic acetylcholine receptors (AChRs) mediate signalling at mature neuromuscular junctions and fetal-type AChRs are necessary for proper synapse development. Each AChR has two neurotransmitter binding sites located at the interface of a principal and a complementary subunit. Although all agonist binding sites have the same core of five aromatic amino acids, the fetal site has ∼30-fold higher affinity for the neurotransmitter ACh. Here we use molecular dynamics simulations of adult ...[more]