Relation Between Circulating Inflammatory Chemokines and Vascular Characteristics in Healthy, Young Children.

ABSTRACT:

Background

Atherosclerosis begins in childhood with the occurrence of inflammatory vascular wall alterations that are detectable with B-mode ultrasound. Chemokines appear to be involved in the development of these alterations given that they occur early in the atherosclerotic pathway as mediators of vascular inflammation. However, this has not extensively been investigated. Therefore, we studied in healthy young children whether chemokines monocyte chemotactic protein 1 (MCP-1), regulated on activation normal T-cell expressed and secreted (RANTES), and vascular and intercellular adhesion molecules (VCAM and ICAM) related to vascular characteristics of the carotid artery.

Methods and results

We obtained demography, anthropometry, and overnight fasting plasma of 139 eight-year

SUBMITTER: Eikendal AL 

PROVIDER: S-EPMC4845277 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature