Ontology highlight
ABSTRACT:
SUBMITTER: Jagannathan L
PROVIDER: S-EPMC4845657 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Jagannathan Lakshmanan L Jose Cynthia C CC Arita Adriana A Kluz Thomas T Sun Hong H Zhang Xiaoru X Yao Yixin Y Kartashov Andrey V AV Barski Artem A Costa Max M Cuddapah Suresh S
Journal of cellular physiology 20151210 7
Oxygen levels range from 2% to 9% in vivo. Atmospheric O2 levels (21%) are known to induce cell proliferation defects and cellular senescence in primary cell cultures. However, the mechanistic basis of the deleterious effects of higher O2 levels is not fully understood. On the other hand, immortalized cells including cancer cell lines, which evade cellular senescence are normally cultured at 21% O2 and the effects of higher O2 on these cells are understudied. Here, we addressed this problem by c ...[more]