Ontology highlight
ABSTRACT:
SUBMITTER: Ranade AR
PROVIDER: S-EPMC4845752 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Ranade Adwait R AR Higgins LeeAnn L Markowski Todd W TW Glaser Nicole N Kashin Dmitry D Bai Ruoli R Hong Kwon Ho KH Hamel Ernest E Höfle Gerhard G Georg Gunda I GI
Journal of medicinal chemistry 20160317 7
Photoaffinity labeling with an epothilone A photoprobe led to the identification of the β-tubulin peptides TARGSQQY and TSRGSQQY as targets of the photoprobe for polymerized tubulin. These peptides represent residues 274-281 in different β-tubulin isotypes. Placing the carbene producing 21-diazo/triazolo moiety of the photoprobe in the vicinity of the TARGSQQY peptide in a homology model of TBB3 predicted a binding pose and conformation of the photoprobe that are very similar to the ones reporte ...[more]