Ontology highlight
ABSTRACT:
SUBMITTER: Bagley SC
PROVIDER: S-EPMC4846031 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Bagley Steven C SC Sirota Marina M Chen Richard R Butte Atul J AJ Altman Russ B RB
PLoS computational biology 20160426 4
Patterns of disease co-occurrence that deviate from statistical independence may represent important constraints on biological mechanism, which sometimes can be explained by shared genetics. In this work we study the relationship between disease co-occurrence and commonly shared genetic architecture of disease. Records of pairs of diseases were combined from two different electronic medical systems (Columbia, Stanford), and compared to a large database of published disease-associated genetic var ...[more]