Morphological and functional remodelling of the neuromuscular junction by skeletal muscle PGC-1?.
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ABSTRACT:
SUBMITTER: Arnold AS
PROVIDER: S-EPMC4846352 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
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Morphological and functional remodelling of the neuromuscular junction by skeletal muscle PGC-1α.
Arnold Anne-Sophie AS Gill Jonathan J Christe Martine M Ruiz Rocío R McGuirk Shawn S St-Pierre Julie J Tabares Lucía L Handschin Christoph C
Nature communications 20140401
The neuromuscular junction (NMJ) exhibits high morphological and functional plasticity. In the mature muscle, the relative levels of physical activity are the major determinants of NMJ function. Classically, motor neuron-mediated activation patterns of skeletal muscle have been thought of as the major drivers of NMJ plasticity and the ensuing fibre-type determination in muscle. Here we use muscle-specific transgenic animals for the peroxisome proliferator-activated receptor γ co-activator 1α (PG ...[more]
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