Ontology highlight
ABSTRACT:
SUBMITTER: Nyberg J
PROVIDER: S-EPMC4846783 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Nyberg J J Karlsson K E KE Jönsson S S Yin Oqp O Miller R R Karlsson M O MO Simonsson Ush U
CPT: pharmacometrics & systems pharmacology 20160415 4
Edoxaban exposure-response relationships from the phase III study evaluating edoxaban for prevention and treatment of venous thromboembolism (VTE) in patients with acute deep vein thrombosis (DVT) and/or pulmonary embolism (PE) were assessed by parametric time-to-event analysis. Statistical significant exposure-response relationships were recurrent VTE with hazard ratio (HR) based on average edoxaban concentration at steady state (Cav) (HRCav) = 0.98 (i.e., change in the HR with every 1 ng/mL in ...[more]