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ABSTRACT: Background and objective
adiponectin is an adipocyte-derived hormone with anti-obesity and anti-diabetic properties. However, higher circulating adiponectin levels are related to poor muscle function and physical disability, which suggests a potential link between adiponectin and risk of falls. Nevertheless, no direct association between circulating adiponectin levels and incident fall risk has been reported. Therefore, this study aimed to investigate the relationship between serum adiponectin levels and incident falls in a population of middle-aged and older adults.Design
a prospective cohort study.Setting
Oroshisho Center in Sendai City, Japan.Subjects
Japanese adults who were ?45 years old (n = 430).Measurements
serum adiponectin levels were measured at baseline, and the subjects were divided into sex-specific tertiles. Data regarding a history of falls were collected via participant recall using a self-reported questionnaire. Incident falls were defined as falls that were experienced by people without a history of falls at baseline.Results
during the 2-year follow-up, 15.6% (67/430) of the subjects experienced an incident fall. In the univariate logistic regression analysis, incident falls were significantly more frequent across the increasing sex-specific serum adiponectin tertiles (P for trend = 0.008). Adjusted odds ratios (95% confidence interval) for incident falls were 2.31 (1.07-4.98) in the middle tertile and 3.61 (1.63-7.99) in the highest tertile; this risk was significantly higher than that for the lowest adiponectin tertile (P for trend = 0.002).Conclusions
the findings of this prospective cohort study indicate that higher serum adiponectin levels may be a predictor of incident falls.
SUBMITTER: Huang C
PROVIDER: S-EPMC4846795 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Huang Cong C Momma Haruki H Niu Kaijun K Chujo Masahiko M Otomo Atsushi A Cui Yufei Y Nagatomi Ryoichi R
Age and ageing 20160323 3
<h4>Background and objective</h4>adiponectin is an adipocyte-derived hormone with anti-obesity and anti-diabetic properties. However, higher circulating adiponectin levels are related to poor muscle function and physical disability, which suggests a potential link between adiponectin and risk of falls. Nevertheless, no direct association between circulating adiponectin levels and incident fall risk has been reported. Therefore, this study aimed to investigate the relationship between serum adipo ...[more]