Ontology highlight
ABSTRACT:
SUBMITTER: Lagoutte E
PROVIDER: S-EPMC4847008 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Lagoutte Emilie E Villeneuve Clémentine C Lafanechère Laurence L Wells Claire M CM Jones Gareth E GE Chavrier Philippe P Rossé Carine C
Scientific reports 20160427
During their metastatic spread, cancer cells need to remodel the extracellular matrix in order to migrate through stromal compartments adjacent to the primary tumor. Dissemination of breast carcinoma cells is mediated by membrane type 1-matrix metalloproteinase (MT1-MMP/MMP14), the main invadopodial matrix degradative component. Here, we identify MT1-MMP as a novel interacting partner of dual-specificity LIM Kinase-1 and -2 (LIMK1/2), and provide several evidence for phosphorylation of tyrosine ...[more]