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Chemical generation and modification of peptides containing multiple dehydroalanines.

ABSTRACT: Chemical formation of dehydroalanine has been widely used for the post-translational modification of proteins and peptides, however methods to incorporate multiple dehydroalanine residues into a single peptide have not been defined. We report the use of methyl 2,5-dibromovalerate which can be used to cleanly carry out this transformation.

SUBMITTER: Morrison PM

PROVIDER: S-EPMC4847484 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Chemical generation and modification of peptides containing multiple dehydroalanines.

Morrison Philip M PM Foley Patrick J PJ Warriner Stuart L SL Webb Michael E ME

Chemical communications (Cambridge, England) 20150901 70

Chemical formation of dehydroalanine has been widely used for the post-translational modification of proteins and peptides, however methods to incorporate multiple dehydroalanine residues into a single peptide have not been defined. We report the use of methyl 2,5-dibromovalerate which can be used to cleanly carry out this transformation. ...[more]

PMID: 26219458

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