Ontology highlight
ABSTRACT:
SUBMITTER: Starosta AL
PROVIDER: S-EPMC4847715 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Cell reports 20141009 2
Bacterial ribosomes stall on polyproline stretches and require the elongation factor P (EF-P) to relieve the arrest. Yet it remains unclear why evolution has favored the development of EF-P rather than selecting against the occurrence of polyproline stretches in proteins. We have discovered that only a single polyproline stretch is invariant across all domains of life, namely a proline triplet in ValS, the tRNA synthetase, that charges tRNA(Val) with valine. Here, we show that expression of ValS ...[more]