Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential.

ABSTRACT: CD11c is an α integrin classically employed to define myeloid dendritic cells. Although there is little information about CD11c expression on human T cells, mouse models have shown an association of CD11c expression with functionally relevant T cell subsets. In the context of genital tract infection, we have previously observed increased expression of CD11c in circulating T cells from mice and women. Microarray analyses of activated effector T cells expressing CD11c derived from naïve mice demonstrated enrichment for natural killer (NK) associated genes. Here we find that murine CD11c+ T cells analyzed by flow cytometry display markers associated with non-conventional T cell subsets, including γδ T cells and invariant natural killer T (iNKT) cells. However, in women, only γδ T cells and CD

SUBMITTER: Qualai J 

PROVIDER: S-EPMC4847787 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature