Ontology highlight
ABSTRACT:
SUBMITTER: Nakajima W
PROVIDER: S-EPMC4847809 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Nakajima Wataru W Sharma Kanika K Hicks Mark A MA Le Ngoc N Brown Rikiara R Krystal Geoffrey W GW Harada Hisashi H
Cancer biology & therapy 20160101 1
Small cell lung cancer (SCLC) is an aggressive tumor type with high mortality. One promising approach for SCLC treatment would be to utilize agents targeting molecular abnormalities regulating resistance to apoptosis. BH3 mimetic antagonists, such as ABT-737 and its orally available derivative ABT-263 (navitoclax) have been developed to block the function of pro-survival BCL-2 family members. The sensitivity of SCLC to these drugs varies over a broad range in vitro and in clinical trials. We hav ...[more]