Ontology highlight
ABSTRACT:
SUBMITTER: Philchenkov AA
PROVIDER: S-EPMC4847820 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Philchenkov Alex A AA Zavelevich Michael P MP Tryndyak Volodymyr P VP Kuiava Ludmila M LM Blokhin Dmitry Yu DY Miura Koh K Silvestri Romano R Pogribny Igor P IP
Cancer biology & therapy 20150101 12
Recently, a series of novel arylthioindole compounds, potent inhibitors of tubulin polymerization and cancer cell growth, were synthesized. In the present study the effects of 2-(1H-pyrrol-3-yl)-3-((3,4,5-trimethoxyphenyl)thio)-1H-indole (ATI5 compound) on cell proliferation, cell cycle progression, and induction of apoptosis in human T-cell acute leukemia Jurkat cells and their multidrug resistant Jurkat/A4 subline were investigated. Treatment of the Jurkat cells with the ATI5 compound for 48 h ...[more]