Ontology highlight
ABSTRACT:
SUBMITTER: Rapireddy S
PROVIDER: S-EPMC4848027 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Rapireddy Srinivas S Nhon Linda L Meehan Robert E RE Franks Jonathan J Stolz Donna Beer DB Tran Dat D Selsted Michael E ME Ly Danith H DH
Journal of the American Chemical Society 20120222 9
Macrocyclic peptides with multiple disulfide cross-linkages, such as those produced by plants and those found in nonhuman primates, as components of the innate immunity, hold great promise for molecular therapy because of their broad biological activities and high chemical, thermal, and enzymatic stability. However, for some, because of their intricate spatial arrangement and elaborate interstrand cross-linkages, they are difficult to prepare de novo in large quantities and high purity, due to t ...[more]