Transcriptomic and epigenomic characterization of the developing bat wing.
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ABSTRACT:
SUBMITTER: Eckalbar WL
PROVIDER: S-EPMC4848140 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Transcriptomic and epigenomic characterization of the developing bat wing.
Eckalbar Walter L WL Schlebusch Stephen A SA Mason Mandy K MK Gill Zoe Z Parker Ash V AV Booker Betty M BM Nishizaki Sierra S Muswamba-Nday Christiane C Terhune Elizabeth E Nevonen Kimberly A KA Makki Nadja N Friedrich Tara T VanderMeer Julia E JE Pollard Katherine S KS Carbone Lucia L Wall Jeff D JD Illing Nicola N Ahituv Nadav N
Nature genetics 20160328 5
Bats are the only mammals capable of powered flight, but little is known about the genetic determinants that shape their wings. Here we generated a genome for Miniopterus natalensis and performed RNA-seq and ChIP-seq (H3K27ac and H3K27me3) analyses on its developing forelimb and hindlimb autopods at sequential embryonic stages to decipher the molecular events that underlie bat wing development. Over 7,000 genes and several long noncoding RNAs, including Tbx5-as1 and Hottip, were differentially e ...[more]
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