Ontology highlight
ABSTRACT:
SUBMITTER: Liu H
PROVIDER: S-EPMC4848513 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Liu Hongmei H Chang Hong H Lv Jia J Jiang Cong C Li Zhenxi Z Wang Fei F Wang Hui H Wang Mingming M Liu Chongyi C Wang Xinyu X Shao Naimin N He Bingwei B Shen Wanwan W Zhang Qiang Q Cheng Yiyun Y
Scientific reports 20160428
Polymers are widely used as non-viral carriers for siRNA delivery, but concern has also arisen in their limited efficacy and inherent toxicity. Whilst many of previous efforts have been documented towards improving the performance of polymers via chemical modifications, the structure-activity relationships (SAR) of these ligand-modified polymers are not well understood. To address this issue, we systemically prepared a library of surface-engineered dendrimers (>300) as the screening pool to disc ...[more]