Ontology highlight
ABSTRACT:
SUBMITTER: Friedrich M
PROVIDER: S-EPMC4848609 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Friedrich Melanie M Setz Christian C Hahn Friedrich F Matthaei Alina A Fraedrich Kirsten K Rauch Pia P Henklein Petra P Traxdorf Maximilian M Fossen Torgils T Schubert Ulrich U
Viruses 20160425 4
The HIV-1 Gag p6 protein regulates the final abscission step of nascent virions from the cell membrane by the action of its two late (L-) domains, which recruit Tsg101 and ALIX, components of the ESCRT system. Even though p6 consists of only 52 amino acids, it is encoded by one of the most polymorphic regions of the HIV-1 gag gene and undergoes various posttranslational modifications including sumoylation, ubiquitination, and phosphorylation. In addition, it mediates the incorporation of the HIV ...[more]