Ontology highlight
ABSTRACT:
SUBMITTER: Nwachukwu JC
PROVIDER: S-EPMC4848761 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Nwachukwu Jerome C JC Srinivasan Sathish S Zheng Yangfan Y Wang Song S Min Jian J Dong Chune C Liao Zongquan Z Nowak Jason J Wright Nicholas J NJ Houtman René R Carlson Kathryn E KE Josan Jatinder S JS Elemento Olivier O Katzenellenbogen John A JA Zhou Hai-Bing HB Nettles Kendall W KW
Molecular systems biology 20160422 4
Some estrogen receptor-α (ERα)-targeted breast cancer therapies such as tamoxifen have tissue-selective or cell-specific activities, while others have similar activities in different cell types. To identify biophysical determinants of cell-specific signaling and breast cancer cell proliferation, we synthesized 241 ERα ligands based on 19 chemical scaffolds, and compared ligand response using quantitative bioassays for canonical ERα activities and X-ray crystallography. Ligands that regulate the ...[more]