Ontology highlight
ABSTRACT:
SUBMITTER: Neves AA
PROVIDER: S-EPMC4848764 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 20151203 4
Glycosylation is a ubiquitous post-translational modification, present in over 50 % of the proteins in the human genome,1 with important roles in cell-cell communication and migration. Interest in glycome profiling has increased with the realization that glycans can be used as biomarkers of many diseases,2 including cancer.3 We report here the first tomographic imaging of glycosylated tissues in live mice by using metabolic labeling and a gadolinium-based bioorthogonal MRI probe. Significant <i> ...[more]