Disturbed macro-connectivity in schizophrenia linked to oligodendrocyte dysfunction: from structural findings to molecules.
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ABSTRACT:
SUBMITTER: Cassoli JS
PROVIDER: S-EPMC4849457 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
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Disturbed macro-connectivity in schizophrenia linked to oligodendrocyte dysfunction: from structural findings to molecules.
Cassoli Juliana Silva JS Guest Paul C PC Malchow Berend B Schmitt Andrea A Falkai Peter P Martins-de-Souza Daniel D
NPJ schizophrenia 20150923
Schizophrenia is a severe psychiatric disorder with multi-factorial characteristics. A number of findings have shown disrupted synaptic connectivity in schizophrenia patients and emerging evidence suggests that this results from dysfunctional oligodendrocytes, the cells responsible for myelinating axons in white matter to promote neuronal conduction. The exact cause of this is not known, although recent imaging and molecular profiling studies of schizophrenia patients have identified changes in ...[more]
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