Ontology highlight
ABSTRACT:
SUBMITTER: Jia Y
PROVIDER: S-EPMC4849474 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Jia Yuanhui Y Li Pishun P Fang Lan L Zhu Haijun H Xu Liangliang L Cheng Hao H Zhang Junying J Li Fei F Feng Yan Y Li Yan Y Li Jialun J Wang Ruiping R Du James X JX Li Jiwen J Chen Taiping T Ji Hongbin H Han Jackie J Yu Wenqiang W Wu Qihan Q Wong Jiemin J
Cell discovery 20160412
Global DNA hypomethylation is a most common epigenetic alteration in cancer, but the mechanism remains elusive. Previous studies demonstrate that UHRF1 but not UHRF2 is required for mediating DNA maintenance methylation by DNMT1. Here we report unexpectedly a conserved function for UHRF1 and UHRF2: inhibiting de novo DNA methylation by functioning as E3 ligases promoting DNMT3A degradation. UHRF1/2 are frequently overexpressed in cancers and we present evidence that UHRF1/2 overexpression downre ...[more]