Constructing de novo H2O2 signaling via induced protein proximity.
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ABSTRACT:
SUBMITTER: Zeng G
PROVIDER: S-EPMC4849873 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Publications
Constructing de novo H2O2 signaling via induced protein proximity.
Zeng Guihua G Zhang Roushu R Xuan Weimin W Wang Wei W Liang Fu-Sen FS
ACS chemical biology 20150318 6
A new chemical strategy has been developed to generate de novo signaling pathways that link a signaling molecule, H2O2, to different downstream cellular events in mammalian cells. This approach combines the reactivity-based H2O2 sensing with the chemically induced protein proximity technology. By chemically modifying abscisic acid with an H2O2-sensitive boronate ester probe, novel H2O2 signaling pathways can be engineered to induce transcription, protein translocation and membrane ruffle formati ...[more]
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